Epidemiology and outcome of acute kidney injury from a tertiary care hospital in India

Epidemiology and outcome of acute kidney injury from a tertiary care hospital in India

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We aimed Shark Cartilage to study the epidemiology and outcome of acute kidney injury (AKI).This is a prospective study of adults aged 18 years or above diagnosed with AKI over a period of 16 months at a tertiary care hospital.Three hundred and nine patients had AKI.

The observed incidence of AKI was eight per 1000 admissions.About 92.2% had community-acquired AKI (CA-AKI), and in 7.

8% it was hospital-acquired AKI (HA-AKI).Etiological factors for AKI were medical in 87.4% of the cases, surgical in 9.

4%, and obstetric 3.2%.Sepsis was the most common (53.

1%) etiology of AKI among the medical cases.Among sepsis, scrub typhus, urosepsis, and pneumonia were the most common causes of AKI.Hypovolemia (9.

4%), biological toxins (8.4%), nephrotoxic drugs and chemicals (7.4%), cardiac causes (7.

4%), and acute glomerulonephritis (1.9%) were other medical causes of AKI.Nearly 38.

2% had multiorgan Board Games failure, 20.1% required vasopressors, 6.1 % required Intensive Care Unit support, and 23.

3% required dialysis.Mortality was 8.7%.

Anemia, use of vasopressor drugs, and need for intensive care support were independent predictive factors for mortality.AKI is common in hospitalized adults in India and leads to significant in-hospital mortality.AKI is largely a CA-AKI and the lesser percentage is due to HA-AKI.

Many causes are potentially preventable.Early fluid resuscitation, effective anti-infective treatment, appropriate antidotes, and timely referral of established AKI patients to centers with dialysis facilities can improve AKI outcomes.